the role of human papilloma virus (hpv) genotyping in recurrent respiratory papillomatosis in rasoul akram hospital

background: the most common laryngeal mass in children is recurrent respiratory papillomatosis (rrp). studies have attempted to correlate viral typing and its aggressiveness. method: 29 patients with histologically confirmed rrp enrolled in adjuvant therapies. patients underwent several surgical interventions. results: hpv genotyping demonstrated 45% hpv-6 and 55% hpv-11. the mean age at the first surgical intervention was 52.39 months (sd=102.28) (range from 4 months to 426 months). the mean number of surgical intervention was 10.39 (sd=7.76) (range from 2 to 30). the mean time of surgical intervals was 4.63 months (sd=4.02) (range from 2 to 24 months). in fourteen patients (48%) tracheotomy was done. all patients who had tracheotomy received alpha-interferon. one of our cases was a male who had pulmonary extension with hpv-6. conclusion: a review of patients with rrp was regarding to hpv genotyping and need for adjuvant therapy and tracheostomy. mean number of surgical procedure was 10/40 and nearly fourteen patients (48%) need to tracheotomy. the clinical differences between hpv6 and hpv11 disease may not be accurately predictable. patients with less age and with hpv-11 seemed to have more severe problems, but these differences were not statistically significant which needs much more investigations for reasonable starting point of evaluation for these differences.